This is the only toothpaste I’ve found that contains both fluoride and nanohydroxyapatite and is manufactured in the US. Does that mean it’s better? We don’t know yet. Fluoride tends to form a very strong surface layer that resists future acid breakdown, but it also limits the depth of cavity remineralization. Should nanohydroxyapatite alone, then, be used at a different time? Say nanoHA in the morning and fluoride at night? Or perhaps a weeks-long regimen with nanoHA followed by a switch to fluoride? We don’t know those answers yet.

As of now, I don’t believe nanoHA’s addition negatively impacts fluoride. My personal routine is TartarEnd toothpaste in AM, floss, then quick once-over with CariFree fluoride paste. At night I use Prevident 5000 (prescription strength fluoride).

Formerly the products were known as: CariFree CTx4 (fluoride) and CTx3 (no fluoride). Both contain 15% nanohydroxyapatite and xylitol. There are three flavors, all very mild: mint, grape, and citrus. Citrus is my favorite. I find the grape is a bit like Dimetapp.

Note: These are not SLS free but I find they don’t irritate my tissues the way OTC brands do, so I think levels are lower.